Synthesis of 5β-cholestane-3α, 7α, 12α, 25-tetrol and 5β-cholestane-3α, 7α, 12α, 24ξ, 25-pentol
نویسندگان
چکیده
منابع مشابه
(20R,24R,25S)-3α,7α,12α,27-Tetraacetoxy-24,26-epoxy-5β-cholestane
In the title anhydro-scymnol tetra-acetate, C(35)H(54)O(9), the fused chair conformation of the cyclo-hexane A/B ring junction is cis with a 5β-H configuration. The compound has a trimethyl-ene oxide ring at position 24,26 and four acetate groups at the 3α,7α,12α,27 positions.
متن کاملBis[3α,7α,12α-tris(4-nitrobenzoyloxy)-5β-cholan-24-yl] disulfide–ethyl acetate–n-hexane (4/4/1)
The crystal structure of the title compound, C(90)H(100)N(6)O(24)S(2)·C(4)H(8)O(2)·0.25C(6)H(14), solved and refined against synchrotron diffraction data, contains two formula units in the asymmetric unit with the all-trans n-hexane mol-ecule having half-occupancy and one of the ethyl acetate mol-ecules disordered over two positions. The two symmetry-independent disulfide mol-ecules are assembl...
متن کاملHepatobiliary disposition of 3α,6α,7α,12α-tetrahydroxy-cholanoyl taurine: A substrate for multiple canalicular transporters
Tetrahydroxy bile acids become major biliary bile acids in Bsep( / ) mice and Fxr( / ) mice fed cholic acid; we characterized disposition of these novel bile acids that also occur in patients with cholestasis. We investigated mouse Mrp2 (mMrp2) and Pglycoprotein [(P-gp) mMdr1a]-mediated transport of a tetrahydroxy bile acid, 6 -OH-taurocholic acid (6 -OH-TC), and its biliary excretion in wild-t...
متن کاملEnterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate ( Raja erinacea).
The sulfated bile alcohol scymnol sulfate (ScyS), 3α,7α,12α,24ξ,26,27-hexahydroxy-5β-cholestane-26(27)-sulfate, is the major bile salt in bile of an elasmobranch, the little skate. To investigate hepatic transport of bile alcohols in skate liver, [3H]ScyS and a potential precursor, 3α,7α,12α-trihydroxy-5β-cholestane (chtriol), were used as model compounds. Their transport into isolated hepatocy...
متن کاملEffect of sodium salts of 3α,12α-dihydroxy-7-oxo-5β-cholanoic and 3,7,12-trioxo-5β-cholanoic acids on verapamil hydrochloride in biophysical–chemical model experiments
It is known that certain bile acids have a promotive effect on the action of some drugs. Special attention is paid to bile acids having oxo groups instead of OH groups in the steroid skeleton of their molecule, since these derivatives have a lower hemolytic potential (membrane toxicity). This study examined the effects of sodium salts of 3α,12α-dihydroxy-7-oxo-5β-cholanoic acid (7-oC) and 3,7,1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1976
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)37019-x